Fluorine-18 labeling of oligonucleotides bearing chemically - Modified ribose - Phosphate backbones

Article abstract of DOI:10.1002/1099-1344(200007)43:8<837::AID-JLCR368>3.0.CO;2-2

We have recently described the labeling of a natural deoxyribose phosphodiester oligonucleotide with fluorine-18 (t_1/2 : 109.8 min) and demonstrated its potential for in vivo imaging in a primate PET study. We here report that the methodology e