Analytical Chemistry p. 2323 - 2326 (1992)
Update date:2022-08-17
Topics:
Richheimer, Steven L.
Tinnermeier, David M.
Timmons, Daniel W.
A reversed-phase high-performance liquid chromatographic (HPLC) method for assaying taxol bulk drug or process samples is described. The method utilizes a commercially available pentafluorophenyl (PFP) packing material that has greater selectivity for taxol and related taxanes than other reversed-phase media tested. The method has been shown to be accurate, linear, precise, specific, and rugged, and can be used to assay the bulk drug and determine its chromatographic purity as well as to assay taxol in process and biomass samples.
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