AN APPROACH TO THE SYNTHESIS OF OPTICALLY ACTIVE TRICHOTHECENES FROM TRI-O-ACETYL-D-GLUCAL

Article abstract of DOI:10.1016/S0040-4039(00)84372-5

A chiral synthesis of the B-C ring system of trichothecenes from tri-O-acetyl-D-glucal by using a photochemical cycloaddition of acetylene to the unsaturated ketone 7, followed by acid-catalyzed rearrangement, is described.