A convenient one-pot synthesis of 1,2-aminoalcohols

Article abstract of DOI:10.1080/00397919808004848

We have developed a rapid facile synthesis of 1,2-aminoalcohols from a variety of aldehyde starting materials. This one pot synthesis proceeds via the in situ formation of cyanohydrin trimethylsilyl ethers and the subsequent addition of Grignard reagents. This method is of particular use where the initial aldehyde exhibits water solubility.

Full text of DOI:10.1080/00397919808004848

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Synthetic Communications:
An International Journal
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Synthetic Organic Chemistry
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A Convenient One-
Pot Synthesis of 1,2-
Aminoalcohols
a
a
a
J. Howarth , D. G. Lloyd & P. McCormac
a
School of Chemical Sciences, Dublin City
University , Glasnevin, Dublin, 9, Ireland
Published online: 20 Aug 2006.
To cite this article: J. Howarth , D. G. Lloyd & P. McCormac (1998) A Convenient
One-Pot Synthesis of 1,2-Aminoalcohols, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry,
28:15, 2751-2759, DOI: 10.1080/00397919808004848
To link to this article: http://dx.doi.org/10.1080/00397919808004848
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