The Orthoester Claisen Rearrangement in the Synthesis of Mycophenolic Acid

DOI: 10.1039/c39910001579

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1579 - 1580 (1991)

Update date:2022-08-10

Topics:

Authors:

Patterson, J. W.

Huang, Glenn T.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39910001579

The orthoester Claisen rearrangement is used as a key reaction in the facile conversion of an acetaldehyde moiety stereospecifically into the (E)-4-methylhex-4-enoic acid side-chain of mycophenolic acid.

Full text of DOI:10.1039/c39910001579

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)- 4-methyl-, ethyl ester

Cas No:13312-25-9

R&D Labs maybe for 13312-25-9

Tianjin SPHINX SCIENTIFIC LAB.

Contact:+86-022-66211289

Address:Tianda high-tech Park. No.80,the 4th Avenue
Longhui qunfeng Chemical Co., Ltd

Contact:86-731-82173407

Address:South-east Industrial Park, Longhui County, Hunan Province, China
SHANDONG QINGYUNCHANGXIN CHEMICAL SCIENCE-TECH CO.,LTD

Contact:86-21-60560171

Address:1689Donghuan Rade,Qingyun County, Dezhou City, Shandong,China
Tianjin Dongchang Fine Chemical Industry Co., Ltd.

Contact:+86-22-29894595

Address:Economic Developing Zone, Ji County, Tianjin, China
Hubei anhuang chemical Co.Ltd

Contact:

Address:308# dongwu avenue dongxihu district wuhan city

Relevant to this article

Kinetics and mechanism of the nucleophilic substitution reaction of imidazole with bis(2,4,6-trichlorophenyl) oxalate and bis(2,4-dinitrophenyl) oxalate

Doi:10.1021/jo951627g
(1996)
Phase transformations of glutamic acid and its decomposition products

Doi:10.1021/cg901303a
(2010)
Mechanism of the oxidation of para-substituted 1-phenylethanols with sodium hypochlorite in acetic acid

Doi:10.1016/S0040-4039(00)00296-3
(2000)
A highly Z-selective isomerization (double-bond migration) procedure for Allyl acetals and Allyl ethers mediated by Nickel complexes

Doi:10.1055/s-1998-2028
(1998)
Reactions of trimethyliodosilane with mono-, di-, and trioxacycloalkanes

Doi:10.1016/0022-328X(91)83021-U
(1991)
Zirconocene-mediated selective synthesis of 1,4-bis(alkynyl)benzenes

Doi:10.1177/1747519820912675
(2020)

Article Doi