β-Butyrolactone as a chiral building block in organic synthesis: A convenient synthesis of MK-0507 keto sulfone

DOI: 10.1016/0957-4166(96)00350-3

Source and publish data:

Tetrahedron Asymmetry p. 2721 - 2724 (1996)

Update date:2022-08-11

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Authors:

Tempkin, Orin

Blacklock, Thomas J.

Burke, J. Andrew

Anastasia, Maria

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Article abstract of DOI:10.1016/0957-4166(96)00350-3

The nucleophilic ring opening of (R)-β-butyrolactone 2 with 2-thiophenethiolate is the key step in a straightforward stereospecific synthesis of keto sulfone 1, a precursor to carbonic anhydrase inhibitor MK-0507.

Full text of DOI:10.1016/0957-4166(96)00350-3

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