Studies in tetrahydrofuran synthesis. Complete β-lactone formation in the bromolactonization of a 2,4-disubstituted β,γ-unsaturated carboxylic acid

Article abstract of DOI:10.1016/0040-4039(95)00034-A

A dienolate aldol/bromolactonization sequence has been used to demonstrate a new stereocontrolled route to protected α-(1-hydroxyalkyl) 2-oxetanones, and thus specifically functionalized tetrahydrofurans.