Bioorganic and Medicinal Chemistry Letters p. 4104 - 4108 (2015)
Update date:2022-08-11
Topics:
Chapman, Timothy M.
Wallace, Claire
Gillen, Kevin J.
Bakrania, Preeti
Khurana, Puneet
Coombs, Peter J.
Fox, Simon
Bureau, Emilie A.
Brownlees, Janet
Melton, David W.
Saxty, Barbara
A high throughput screen allowed the identification of N-hydroxyimide inhibitors of ERCC1-XPF endonuclease activity with micromolar potency, but they showed undesirable selectivity profiles against FEN-1. A scaffold hop to a hydroxypyrimidinone template g
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