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against the tested dermatophytic species Asper-
gillus alutaceus and Rhodotorula rubra compared
with tolnaftate. Compound 7e also revealed inhi-
bitory activity against Pencillium aurantiogriseum
and Aspergillus sydowii; tolnaftate showed no
activity against either of these fungi. Compound
7c exhibited weak and selective activity against
Geotrichum candidum and Mucor circinelloides.
Some ef®cacy of compound 7d was found against
R. rubra, P. aurantiogriseum and G. candidum.
The latter two fungi were not sensitive to tolnaf-
tate. Compound 7f was equipotent with the
reference drug against Mucor circinelloides. The
derivatives 6a±e, 7a, 7b and 7g were completely
inactive against all the tested fungal isolates listed
in Tables 3 and 4 .
In conclusion, potassium salts of N, N-disub-
stituted dithiocarbamic acid displayed higher and
broad spectrum activity against true dermatophytes,
as well as opportunistic nondermatophyte fungal
species among all the tested compounds. Combi-
nation of these derivatives with a naphthaline
nucleus through an acetyl spacer resulted in a
drastic decrease or complete loss of antifungal
activity of some derivatives in comparison with
tolnaftate. Derivatives 6a±g were much less active
than their congeners 7a±g, which may be attributed
to the presence of the methoxy group in 7a±g. The
morpholino analogue 7e was the most active
compound in the series 7a±g.
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Acknowledgements
We thank Dr Ernst Urban, Institut fuÈr Pharmazeu-
È
tische Chemie der Universitat Wien, Austria for his
help in carrying out the MS measurements.
È
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