A practical approach for the optically pure N-Methyl-α- amino acids

Article abstract of DOI:10.1016/S0040-4039(98)00111-7

A new practical synthesis of N-Methyl-α-amino acids by racemization free methodology has been developed. The method involves the reductive cleavage of N-protected oxazotidinones using hydrogen in the presence of Pd/C to give the title compounds in quantitative yields.