Enantioselective total synthesis of (+)-stephadiamine through bioinspired aza-benzilic acid type rearrangement

Article abstract of DOI:10.1021/jacs.1c00047

We report the first enantioselective total syntheses of the hasubanan alkaloid (-)-metaphanine and the norhasubanan alkaloid (+)-stephadiamine. Key features of these syntheses include diastereoselective oxidative phenolic coupling reaction and subsequent