Tetrahedron Letters p. 4281 - 4282 (1996)
Update date:2022-08-17
Topics:
Harrowven, David C.
Poon, Hon Suen
When a solution of diethyl maleate and acetophenone is added to a cooled (-78°C) solution of a lithium amide the maleate derivative 3 is given in good yield. Pre-treatment of the lithium amide with TMSCl alters the course of this reaction dramatically. With half an equivalent of this additive the Michael adduct 4 is given in 62% yield while employing three equivalents leads to the silyl enol ether 5 in >85% yield.
View More
Contact:0027-717-456976
Address:2ND FLOOR, 325 VAUSE ROAD, OVERPORT, 4001, SOUTH AFRICA
Contact:+86-27-67841589
Address:Add: 999 Gaoxin Road, Donghu New Technology Development Zone, Wuhan City, Hubei, China
Huangshi Meifeng Chemical Co.,ltd.
Contact:+86-714-6516706
Address:1941-4-3#,Hubin Avenue,Huangshi,Hubei,China
Hangzhou Maytime Bio-Tech Co.,Ltd.
website:http://www.maytime.com.cn
Contact:+86-571-88925295 88920965
Address:NO.2-1701 Ganghui Central Ningwei Street, Xiaoshan Hangzhou Zhejiang China
Contact:+49-9398-993127
Address:Untertorstr. 27
Doi:10.1002/anie.201907668
(2019)Doi:10.1021/ja4088743
(2013)Doi:10.1134/S0036024416020163
(2016)Doi:10.1021/jo00223a041
(1985)Doi:10.1002/adsc.200800632
(2009)Doi:10.1016/j.tet.2013.03.018
(2013)
