Preferential Cryatallization of 2-Amino-2-phenylethanol and Its Application as a Resolving Agent

Article abstract of DOI:10.1246/bcsj.55.1188

(+/-)-2-Amino-2-phenylethanol (phenylglycinol) prepared from (+/-)-2-amino-2-phenylacetic acid (DL-phenylglycine) by lithium aluminium hydride reduction was efficiently resolved into a pair of optically active forms by preferential crystallization.The optically active amino alcohol was successfully applied as a basic resolving agent to the resolution of tartaric acid, 2-hydroxy-2-phenylpropionic acid, 2-hydroxy-3-phenylpropionic acid, 2-phenylpropionic acid, and 2-phenyl-2-ureidoacetic acid.