Scandium(III) triflate-catalyzed coumarin synthesis

Article abstract of DOI:10.1080/00397910802369513

Scandium(III) triflate is an excellent catalyst in the von Pechmann condensation. The solvent-free catalytic reactions proceed smoothly with a range of phenols and β-ketoesters in the presence of 10 mol% scandium(III) triflate at 80°C. This simple method affords various 4-substituted coumarins in good to excellent yield and is superior to the classical method in several aspects: solvent-free conditions, short reaction times, a decreased catalyst loading, a mild reaction temperature, and an easy workup. Copyright Taylor & Francis Group, LLC.