A REGIOSELECTIVE ENOLATE FORMATION OF TRIMETHYLSILYLMETHYL KETONES APPLICATION TO THE (E)-SELECTIVE SYNTHESIS OF α,β-UNSATURATED KETONES

Article abstract of DOI:10.1016/S0040-4039(01)91193-1

Two possible enolate anions of trimethylsilylmethyl ketones have been prepared regioselectively by the appropriate choice of base.The one directed to the silylmethyl site behaves as a highly reactive and (E)-selective condensation reagent to aldehydes.