Journal of the American Chemical Society p. 4895 - 4902 (1984)
Update date:2022-08-11
Topics:
Barna, Jennifer C. J.
Williams, Dudley H.
Stone, David J. M.
Leung, T.-W. Christina
Doddrell, David M.
By a combination of chemical, 1H and 13C NMR, and mass spectrometric studies, the structures of the five major components of the antibiotic teicoplanin, produced by Actinoplanes teichomyceticus, have been elucidated.The components all have structures closely related to those of the glycopeptide antibiotics of the vancomycin group.The teicoplanin components are differentiated from one another by the presence of various N-acylglucosamine moieties, where the acyl group is a C10 or C11 fatty acid.Such groups are not present in any other known member of the vancomycin group.
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