Angewandte Chemie - International Edition p. 1143 - 1147 (2013)
Update date:2022-08-12
Topics:
Jenner, Matthew
Frank, Sarah
Kampa, Annette
Kohlhaas, Christoph
P?plau, Petra
Briggs, Geoff S.
Piel, J?rn
Oldham, Neil J.
Branching out: The substrate specificity profiles for a range of ketosynthase (KS) domains from trans-AT PKSs are reported. Evidence is provided that a sterically demanding amino acid residue adjacent to the active-site Cys residue confers specificity towards non-β-methyl-branched substrates (see scheme). Copyright
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