Cis (1S,3R)-1-(9-adenyl)-3-hydroxycyclopentane inhibits the respiratory burst from polymorphonuclear leukocytes and has in vivo efficacy in an acute and chronic model of inflammation

Article abstract of DOI:10.1080/07328319608002028

The adenine-containing carbocyclic nucleosides 1 and 2 were synthesized in optically active form and have been shown to effectively inhibit interferon- gamma priming of Lewis (LEW/N) rat air pouch-derived PMNs. Compound 2 was also shown to have in vivo activity in a LEW/N rat antigen-induced arthritis model which assesses acute and chronic inflammation.

Full text of DOI:10.1080/07328319608002028

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Cis (IS,3R)-1-(9-Adenyl)-3-
Hydroxycyclopentane Inhibits
the Respiratory Burst from
Polymorphonuclear Leukocytes and
Has In Vivo Efficacy in an Acute and
Chronic Model of Inflammation
David R. Borcherding a , Brent T. Butler a , Matthew D. Linnik a ,
Shujaath Mehdi a , Mark W. Dudley a & Carl K. Edwards III a
a Marion Merrell Dow Research Institute 2110 East Galbraith
Road , P. O. Box 156300, Cincinnati, Ohio, 45215-6300
Published online: 15 Aug 2006.
To cite this article: David R. Borcherding , Brent T. Butler , Matthew D. Linnik , Shujaath Mehdi ,
Mark W. Dudley & Carl K. Edwards III (1996) Cis (IS,3R)-1-(9-Adenyl)-3-Hydroxycyclopentane
Inhibits the Respiratory Burst from Polymorphonuclear Leukocytes and Has In Vivo Efficacy in
an Acute and Chronic Model of Inflammation, Nucleosides and Nucleotides, 15:5, 967-979, DOI:
10.1080/07328319608002028
To link to this article: http://dx.doi.org/10.1080/07328319608002028
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