ANTIFUNGAL PHLOROGLUCINOL DERIVATIVES AND LIPOPHILIC FLAVONOIDS FROM HELICHRYSUM DECUMBENS

Article abstract of DOI:10.1016/S0031-9422(00)97809-9

From the aerial parts of Helichrysum decumbens, three new antifungal phloroglucinol derivatives have been identified.Their structures have been established by UV, IR, EIMS, FAB-MS, 1H NMR and 13C NMR techniques.In addition, the highly methylated flavonoids 3,5-dihydroxy-6,7,8-trimethoxyflavone, 5,7-dihydroxy-3,6,8-trimethoxyflavone and 3,5-dihydroxy-6,7-dimethoxyflavone have been detected, the latter being a new naturally occurring compound.The phloroglucinols prevented the growth of Cladosporium herbarum in a bio-assay.These secondary metabolites are externally deposited on the plant surfaces. Key Word Index-Helichrysum decumbens; Compositae; prenylated phloroglucinols; antifungal compounds; lipophilic flavonoids; 3,5-dihydroxy-6,7-dimethoxyflavone.