1,2 Asymmetric induction in the TiCl4 mediated alkylation of α-methyl-β-silyloxy ketones with Grignard reagents

DOI: 10.1016/S0040-4039(97)00735-1

Source and publish data:

Tetrahedron Letters p. 3785 - 3788 (1997)

Update date:2022-08-25

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Authors:

Bartoli, Giuseppe

Bosco, Marcella

Sambri, Letizia

Marcantoni, Enrico

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Article abstract of DOI:10.1016/S0040-4039(97)00735-1

Transmetallation of an α-methyl-β-silyloxy ketone with TiCl₄ in toluene affords a cyclic chelation complex which undergoes highly stereoselective alkylation from Grignard reagents at the less hindered side.

Full text of DOI:10.1016/S0040-4039(97)00735-1

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