Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycin

DOI: 10.1016/0960-894X(96)00398-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2193 - 2196 (1996)

Update date:2022-08-17

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Authors:

Sinclair, Peter J.

Wong, Frederick

Staruch, Mary Jo

Wiederrecht, Greg

Parsons, William H.

Dumont, Francis

Wyvratt, Matthew

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Article abstract of DOI:10.1016/0960-894X(96)00398-8

The synthesis of naphthyl- and indolyl-ethers of the immunosuppressive macrolide ascomycin using pentavalent bismuth reagents is described. The in vitro activities of the aryl ether analogs are reported. The indole ether analogs show increased immunosuppr

Full text of DOI:10.1016/0960-894X(96)00398-8

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