THE SELECTIVE OXIDATION OF ALDOSES AND ALDONIC ACIDS TO 2-KETOALDONIC ACIDS WITH LEAD-MODIFIED PLATINUM-ON-CARBON CATALYSTS

Article abstract of DOI:10.1016/S0008-6215(00)90265-9

Aldoses and aldonic acids have been oxidised with oxygen and air at 55 deg in water, using Pt/C catalysts.After oxidation of the reducing group, if available, the primary hydroxyl group is preferentially oxidised using an unmodified catalyst.Addition of a lead(II) salt changes the preference dramatically towards oxidation at the position α to the carboxyl group.Provided that oxygen transfer to the liquid phase is carefully controlled in order to prevent deactivation of the catalyst, 2-ketoaldonic acids can be prepared in high yields.