Journal of Pharmaceutical Sciences p. 1175 - 1178 (1976)
Update date:2022-08-11
Topics:
Indelicato
Wilham
Cerimele
The rate of hydrolysis of the formyl moiety of cefamandole nafate was determined as a function of pH, temperature, and concentration of added sodium carbonate or tromethamine. The reaction rate was sensitive to hydroxide ion in the pH 5.5-8.0 range with half life values of hours to minutes. Hydrolysis was rapid upon the addition of sodium carbonate or tromethamine. Chirality in the 7 D mandelamido side chain was unaffected by hydrolysis.
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