A New Method of Synthesizing 7-(2-Hydroxy-5-oxo-1-cyclopentenyl)heptanoic Acid and Related Compounds

DOI: 10.1246/bcsj.61.2401

Source and publish data:

Bulletin of the Chemical Society of Japan p. 2401 - 2404 (1988)

Update date:2022-08-12

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Authors:

Naora, Hirokazu

Ohnuki, Takashi

Nakamura, Asao

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Article abstract of DOI:10.1246/bcsj.61.2401

A useful prostanoid synthon, 7-(2-hydroxy-5-oxo-1-cyclopentenyl)heptanoic acid (3), was prepared from commercially available cyclooctanone in two steps.Nine other related cyclopentanoids which are also valuable synthons for prostaglandins were obtained from 3 in reasonable yields via several steps.The procedure is capable of generating these synthons on a laboratory scale.

Full text of DOI:10.1246/bcsj.61.2401

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