Bioorganic and Medicinal Chemistry Letters p. 2593 - 2598 (1997)
Update date:2022-08-11
Topics:
Bellevue III, Frank H.
Woster, Patrick M.
Edwards, David J.
He, Kan
Hollenberg, Paul F.
The recently isolated inhibitor of cytochrome P450 CYP3A4, 6',7'-dihydroxybergamottin (6,7-DHB), was synthesized by an efficient route that is readily adaptable to the production of analogues. The compound was evaluated as an inhibitor of 3A4 in a purified enzyme preparation, as well as against human liver microsomes and human 3A4 expressed in Escherichia coil membrane. In each case, 6,7-DHB proved to be a potent NADPH- and time dependent inactivator of 3A4.
View MoreContact:0833-5590788/5590338/5590055
Address:Victory in the town of Red Star Village,Mount Emei City,industrial concentration area storage processing logistics parkpark
Beijing Wisdom Chemicals Co., Ltd.
Contact:+86-10-52350335
Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Binzhou Holly Pharmaceutical Co.,Ltd.
Contact:74517
Address:No.15 Dapu Road,Huangpu District Shanghai,P.R.China
Zibo Jujin Chemical Industry Co., Ltd.（Dongming Jujin Chemical Industry Co., Ltd. ）
Contact:+86-533-2975022
Address:No.99 Shanquan Road, Zhangdian District
Nanjing Fubang Chemical Co.,Ltd
Contact:+86-25-83179199
Address:5F,Tianzheng international plaza,No399 Zhongyang Road ,Nanjing China
Doi:10.1016/j.molcata.2014.07.002
(2014)Doi:10.1002/hlca.19770600503
(1977)Doi:10.1039/d0dt02606a
(2020)Doi:10.1016/j.dyepig.2018.05.045
(2018)Doi:10.1016/S0040-4039(00)91262-0
(1975)Doi:10.1103/PhysRev.54.1072
(1938)
