Drastic solvent effect on lipase-catalyzed enantioselective hydrolysis of prochiral 1,4-dihydropyridines

DOI: 10.1016/S0040-4039(00)60861-4

Source and publish data:

Tetrahedron Letters p. 7157 - 7160 (1992)

Update date:2022-08-04

Topics:

Authors:

Hirose, Yoshihiko

Kariya, Kinya

Sasaki, Ikuharu

Kurono, Yoshiaki

Ebiike, Hirosato

Achiwa, Kazuo

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Article abstract of DOI:10.1016/S0040-4039(00)60861-4

Two enantiomers of 1,4-dihydropyridine compounds have been obtained with high enantiomeric purity by lipase-catalyzed hydrolysis in organic solvent saturated with water. Enantioselectivity of this reaction is dependent on the solvent used.

Full text of DOI:10.1016/S0040-4039(00)60861-4

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