Diastereoselective Addition of Organocuprates on 1,4-Dihydropyridine-3-carboxaldehydes. Synthesis of Chiral 1,4-Dihydropyridyl-3-alcohols and Pyridyl-3-alcohols

DOI: 10.1016/0040-4039(93)85055-2

Source and publish data:

Tetrahedron Letters p. 6399 - 6402 (1993)

Update date:2022-08-29

Topics:

Authors:

Mangeney, Pierre

Gosmini, Romain

Raussou, Sabine

Commercon, Monique

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Article abstract of DOI:10.1016/0040-4039(93)85055-2

Chiral 1,4-dihydropyridyl-3-alcohols are obtained via a diastereoselective (de 90percent->95percent) 1,2 addition of organocuprates on chiral 1,4-dihydropyridine-3-carboxaldehydes and are transformed into chiral pyridyl-3-alcohols (90percent->95percent).

Full text of DOI:10.1016/0040-4039(93)85055-2

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