Chemoselective asymmetric hydrogenation of a α, β-unsaturated carbonyl compounds to allylic alcohols catalysed by BF4- aminophosphine

Article abstract of DOI:10.1016/0022-328X(92)83231-6

Assymmetric hydrogenation of (E)-4-phenyl-3-buten-2-one by use of BF4 and o-dimethylaminophenyldiphenylphosphine afforded (E)-4-phenyl-3-buten-2-ol in 97percent chemoselectivity and in 65percent enantiomeric excess.A mixed ligand iridium dihydride complex containing both BINAP and the aminophosphine ligand has been shown to be the catalytically active species.