Synthesis of 2,4-difluoroaniline and 1,3-difluorobenzene from 1,2,4- trichlorbenzene

Article abstract of DOI:10.1080/00397919408011503

Nitration of inexpensive 1,2,4-trichlorobenzene gave 2,4,5- trichloronitrobenzene (90%) which was treated with KF to form 2,4-difluoro- 5-chloronitrobenzene (70%). This was selectively hydrogenated over Pd / C to give 2,4-difluoroaniline (80%). Deamination afforded 1,3-difluorobenzene. The sequence avoids the need for costly 1,3-dichlorobenzene.

Full text of DOI:10.1080/00397919408011503

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Synthetic Communications: An
International Journal for Rapid
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Synthesis of 2,4-Difluoroaniline
and 1,3-Difluorobenzene from
1,2,4-Trichlorbenzene
James Mason a & David J. Milner a
a Zeneca Specialties Research Centre , Blackley,
Manchester, M9 3DA, United Kingdom
Published online: 04 Jan 2007.
To cite this article: James Mason & David J. Milner (1994) Synthesis of 2,4-
Difluoroaniline and 1,3-Difluorobenzene from 1,2,4-Trichlorbenzene, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 24:4, 529-532, DOI: 10.1080/00397919408011503
To link to this article: http://dx.doi.org/10.1080/00397919408011503
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