Journal of labelled compounds and radiopharmaceuticals p. 281 - 289 (2002)
Update date:2022-08-17
Topics:
Jewett, Douglas M.
Kilbourn, Michael R.
[11C]Paraquat was synthesized by the reaction of [11C]methyl triflate with the mono-triflate salt of 1-methyl-[4,4′]bipyridinyl. The product was selectively separated from the precursor by a microcolumn of Chelex 100 ion exchange resin. The method was applied to the synthesis of a variety of [N-methyl-11C]bisquaternary ammonium compounds. This is the first reported use of a chelating cation exchange resin for the selective purification of organic dications. Copyright
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