Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs

DOI: 10.1016/j.bmc.2015.04.022

Source and publish data:

Bioorganic and Medicinal Chemistry p. 3542 - 3551 (2015)

Update date:2022-08-28

Topics:

Authors:

Yadav, Arun A.

Chee, Gaik-Lean

Wu, Xing

Patel, Daywin

Yalowich, Jack C.

Hasinoff, Brian B.

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Article abstract of DOI:10.1016/j.bmc.2015.04.022

Drugs that target DNA topoisomerase II, such as the epipodophyllotoxin etoposide, are a clinically important class of anticancer agents. A recently published X-ray structure of a ternary complex of etoposide, cleaved DNA and topoisomerase IIβ showed that

Full text of DOI:10.1016/j.bmc.2015.04.022

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