Heterocyclic lactam derivatives as dual angiotensin converting enzyme and neutral endopeptidase 24.11 inhibitors

DOI: 10.1021/jm00076a010

Source and publish data:

Journal of Medicinal Chemistry p. 3829 - 3833 (1993)

Update date:2022-08-30

Topics:

Authors:

Stanton Stanton

Sperbeck

Trapani Trapani

Cote Cote

Sakane Sakane

Berry Berry

Ghai Ghai

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Article abstract of DOI:10.1021/jm00076a010

A series of 13- and 14-membered ring lactam derivatives 9a,b, 10, 11, and 12a-c was prepared from L-cysteine. Compounds 9a,b and 12a,b were tested in vitro for inhibition of neutral endopeptidase 24.11 (NEP) and angiotensin converting enzyme (ACE) inhibit

Full text of DOI:10.1021/jm00076a010

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