PLE-catalyzed resolution of α-substituted β-ketoesters application to the synthesis of (+)-Nitramine and (-)-Isonitramine

Article abstract of DOI:10.1016/S0957-4166(00)80054-3

Substituted β-ketoesters can be prepared in enantiomerically pure form by pig liver esterase catalyzed hydrolysis of their racemic precursors. With the asymmetric carbon atom possessing a quaternary centre, (+)-Nitramine and (-)-Isonitramine have been syn