Journal of Medicinal Chemistry p. 177 - 183 (1994)
Update date:2022-08-17
Topics:
Hanna
Bhattacharya
Robins
Avery
Revankar
A number of N9-alkyl-substituted purines and purine ribonucleosides have been synthesized as congeners of sulfinosine and evaluated for their antileukemic activity in mice. NaH-mediated alkylation of 6-chloropurine (4) and 2-amino-6-chloropurine (5) with
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