Efficient synthesis of 7-, 8- and 9-membered cyclic allyltitanium compounds and their stereoselective addition reaction with aldehydes and imines

Article abstract of DOI:10.1016/S0040-4039(97)00484-X

Reaction of 7-, 8- and 9-membered cyclic allylic compounds 2 with (η²propene)Ti(O-i-Pr)₂ (1) via an oxidative addition pathway provides the corresponding allylic titanium compounds, which, in turn, react with aldehydes and imines stereoselectively, thus providing an efficient and stereoselective method for synthesizing cycloalkenes having a side chain at the allylic position.