Genistein and fluorinated analogs suppress agonist-induced airway smooth muscle contraction

Article abstract of DOI:10.1016/S0960-894X(97)00215-1

4'-fluoro-5,7-dihydroxyisoflavone (DHIF), 2',4'-difluoro-5,7-DHIF and 3',4'-difluoro-5,7-DHIF were synthesized as analogs of the naturally occuring 5,7,4'-trihydroxyisonavone (genistein). On guinea-pig trachea, genistein exhibited potent relaxant effect on strips precontracted with acetylcholine, KCl and histamine and a potent inhibitory effect on KCl-induced contraction. Fluorinated compounds showed less activity.