Bioorganic and Medicinal Chemistry Letters p. 1323 - 1326 (1997)
Update date:2022-08-17
Topics:
Bois, Frederic
Desfougeres, Aline
Boumendjel, Ahcene
Mariotte, Anne-Marie
Bessard, Germain
Caron, Francoise
Devillier, Philippe
4'-fluoro-5,7-dihydroxyisoflavone (DHIF), 2',4'-difluoro-5,7-DHIF and 3',4'-difluoro-5,7-DHIF were synthesized as analogs of the naturally occuring 5,7,4'-trihydroxyisonavone (genistein). On guinea-pig trachea, genistein exhibited potent relaxant effect on strips precontracted with acetylcholine, KCl and histamine and a potent inhibitory effect on KCl-induced contraction. Fluorinated compounds showed less activity.
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