Genistein and fluorinated analogs suppress agonist-induced airway smooth muscle contraction

DOI: 10.1016/S0960-894X(97)00215-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1323 - 1326 (1997)

Update date:2022-08-17

Topics:

Authors:

Bois, Frederic

Desfougeres, Aline

Boumendjel, Ahcene

Mariotte, Anne-Marie

Bessard, Germain

Caron, Francoise

Devillier, Philippe

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Article abstract of DOI:10.1016/S0960-894X(97)00215-1

4'-fluoro-5,7-dihydroxyisoflavone (DHIF), 2',4'-difluoro-5,7-DHIF and 3',4'-difluoro-5,7-DHIF were synthesized as analogs of the naturally occuring 5,7,4'-trihydroxyisonavone (genistein). On guinea-pig trachea, genistein exhibited potent relaxant effect on strips precontracted with acetylcholine, KCl and histamine and a potent inhibitory effect on KCl-induced contraction. Fluorinated compounds showed less activity.

Full text of DOI:10.1016/S0960-894X(97)00215-1

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