Ring D Modifications of Ellipticine. Part 1. New Ellipticine Derivatives from 1-Cyano-6-Methylellipticine.

DOI: 10.1016/S0040-4020(01)86971-4

Source and publish data:

Tetrahedron p. 2551 - 2560 (1994)

Update date:2022-08-16

Topics:

Authors:

Boogaard, Adrian T.

Pandit, Upendra K

Koomen, Gerrit-Jan

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Article abstract of DOI:10.1016/S0040-4020(01)86971-4

New ellipticine derivatives are synthesized by modification of the cyanogroup of 1-cyano-6-methylellipticine.This resulted in the formation of 1-acetyl- and 1-acetamido-6-methylellipticine.Deprotonation of 1-cyano-6-methylellipticine under the influence of Palladium catalyst leads to a new annelated ellipticine (9).From the derivatives obtained, 9 showed the highest cytostatic activity.

Full text of DOI:10.1016/S0040-4020(01)86971-4

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