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The present study offers a proof-of-principle and indicates that
proline/glutamic acid and hystidine lysine as a hydrophilic
catalyzed asymmetric intermolecular aldol reactions, J. Am.
Chem. Soc., 2003, 125(9), 2475–2479.
residue and leucine, phenylalanine, valine as hydrophobic 15 B. List, Proline-catalyzed asymmetric reactions, Tetrahedron,
residues in 8aa have signicant potentials in catalysis. The 2002, 58(28), 5573–5590.
carboxyl group of glutamic acid, lysine and histidine provided 16 J. Kofoed, J. Nielsen and J.-L. Reymond, Discovery of new
an obvious site for facile attachment of structural units, which
can provide alternate hydrogen bonding arrays. The secondary
peptide-based catalysts for the direct asymmetric aldol
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structures of the peptides were studied using CD spectra and 17 W. Zou, I. Ibrahem, P. Dziedzic, H. Sund ´e n and A. C ´o rdova,
FT-IR. 8aa has the advantage of functioning as a powerful
asymmetric organocatalyst in aqueous medium and of being
reusable.
Small peptides as modular catalysts for the direct
asymmetric aldol reaction: ancient peptides with aldolase
enzyme activity, Chem. Commun., 2005, (39), 4946–4948.
8 W. Huang, H. Tian, H. Xu, L. Zheng, Q. Liu and S. Zhang, L-
Valine dipeptide organocatalysts with two amide units for
the direct asymmetric aldol reaction in brine, Catal. Lett.,
2011, 141(6), 872–876.
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