Enzymatic kinetic resolution of (±)-4-acetoxy[2.2] paracyclophane by candida cylindracea lipase. An efficient route for the preparation of(+)-R-4-Hydroxy- and (+)-S-4-acetoxy[2.2)paracyclophane

Article abstract of DOI:10.1016/S0040-4020(97)00758-8

The enzymatic kinetic resolution of (±)-4-acetoxy[2.2]paracyclophane by Candida cylindracea lipase was investigated in water and in a two-phase aqueous organic system. The (+)-(R)4-hydroxy- and (c)-(S)-4-acetoxy[2,2]-paracyclophanes were isolated in excellent yields and high enantiomeric excesses. The resolution was carried out on multi-gram scale in hexane-water at 40°C.