An effective synthesis of 2-trifluoromethyl- or 2-(1,1-difluoroalkyl)thiophenes

Article abstract of DOI:10.1055/s-1997-1204

Various thiophenecarboxylates carrying a 2-trifluoromethyl, 2-(1,1-difluoroalkyl) or 2-polyfluoroalkyl group are synthesized conveniently from reaction of α-fluoroalkyl ketones 1, aldehydes 2 or ethyl α-fluoroalkylacetates 3 with methyl (or ethyl) 2-sulfa