5-Diethoxyphosphoryl-5-methyl-1-pyrroline N-Oxide (DEPMPO): a New Phosphorylated Nitrone for the efficient In Vitro and In Vivo Spin Trapping of Oxygen-centred Radicals

Article abstract of DOI:10.1039/c39940001793

5-Diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO), a newly synthesized spin trap, is used for the in vitro spin trapping of hydroxyl and superoxide radicals, and though the spin trapping rates are close to those reported for 5,5-dimethyl-1-pyrroline N-oxide (DMPO), the DEPMPO-superoxide spin adduct is significantly more persistent than its DMPO analogue, a difference which allows the detection of superoxide during the reperfusion of ischaemic isolated rat hearts.

Full text of DOI:10.1039/c39940001793

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