4-Cyano-2-butenyl group: A new type of protecting group in oligonucleotide synthesis via phosphoramidite approach

Article abstract of DOI:10.1016/S0040-4039(96)01496-7

4-Cyano-2-butenyl (CB) is a new type of protecting group for the internucleotide bonds in the synthesis of oligodeoxyribonucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild conditions by a δ-elimination pathway using aqueous ammonium hydroxide.