4-Cyano-2-butenyl group: A new type of protecting group in oligonucleotide synthesis via phosphoramidite approach

Article abstract of DOI:10.1080/07328319708006260

4-Cyano-2-butenyl (CB) is a new type of protecting group for the internucleotidic bonds in the synthesis of oligodeoxyribonueleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild conditions by a δ-elimination pathway using aqueous ammonium hydroxide.

Full text of DOI:10.1080/07328319708006260

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Nucleosides and Nucleotides
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4-Cyano-2-butenyl Group: A New Type
of Protecting Group in Oligonucleotide
Synthesis via Phosphoramidite
Approach
Vasulinga T. Ravikumar a , Zacharia S. Cheruvallath a & Douglas
L. Cole a
a Isis Pharmaceuticals , 2292 Faraday Avenue, Carlsbad, CA,
92008
Published online: 16 Aug 2006.
To cite this article: Vasulinga T. Ravikumar , Zacharia S. Cheruvallath & Douglas L. Cole
(1997) 4-Cyano-2-butenyl Group: A New Type of Protecting Group in Oligonucleotide Synthesis
via Phosphoramidite Approach, Nucleosides and Nucleotides, 16:7-9, 1709-1712, DOI:
10.1080/07328319708006260
To link to this article: http://dx.doi.org/10.1080/07328319708006260
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