Synthesis of a C-15/C-27 Segment of Venturicidine

Article abstract of DOI:10.1016/S0040-4039(00)76958-9

The C-15/C-27 segment of venturicidine contains a 1,3,5,n-anti-methylated alkyl chain, which resembles syndiotactic polypropylene and should therefore favor an extended conformation.A synthetic scheme is presented, by which such structures are generated in a cycle of four steps per three stereogenic centers.This allowed the synthesis of the above mentioned venturicidine fragment in 15 steps from propionaldehyde.