A NOVEL SYNTHESIS OF THE α-HYDROXYKETONE MOIETY OF ANTHRACYCLINONES BY THE USE OF 2-TRIMETHYLSILYLETHYNYLCERIUM(III) REAGENTS

Article abstract of DOI:10.1246/cl.1984.1543

2-trimethylsilylethynylcerium(III) reagents were found to efficiently react with 1,2,3,4-tetrahydronaphthalene-2-one derivatives, giving the corresponding adducts in high yields.Hydration of the adducts readily afforded the α-hydroxy methyl ketones which are versatile synthetic intermediates of natural and unnatural anthracyclinones.