A convenient one-pot preparation of disubstituted phosphinic acids derived from simple amino acids and proline

DOI: 10.1055/s-1995-4050

Source and publish data:

Synthesis p. 1074 - 1076 (1995)

Update date:2022-08-29

Topics:

Authors:

Borloo Borloo

Jiao Jiao

Wojtowicz

Rajan Rajan

Verbruggen

Augustyns

Haemers Haemers

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Article abstract of DOI:10.1055/s-1995-4050

A facile method for the preparation of both 2-pyrrolidinyl-substituted phosphinic acids and 1-aminoalkylphosphinic acids is described. Reaction of 1-pyrroline trimer or N-tritylalkanamine with bis(trimethylsilyl)phosphonite, followed by silylation with N,O-bis(trimethylsilyl)acetamide gives an intermediate which is used in a Michael addition reaction or an Arbuzov reaction.

Full text of DOI:10.1055/s-1995-4050

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