A new synthesis of 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT)

Article abstract of DOI:10.1080/00397919208020492

A new synthesis method for 8-OH-DPAT, a specific agonist at the 5-HT(1A) serotonin receptor, is described. It employs the Curtius degradation of a tetralin carboxylic acid easily prepared from (2-methoxy benzyl) succinic acid by Friedel-Craft cyclisation.

Full text of DOI:10.1080/00397919208020492

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A New Synthesis of 8-
Hydroxy-2-di-n-propylamino-
tetralin (8-OH-DPAT)
Michel Langlois a & Florence Gaudy a
a CNRS-CERCOA, 2-8 rue Henri Dunant, F-94320,
Thiais
Published online: 23 Sep 2006.
To cite this article: Michel Langlois & Florence Gaudy (1992): A New Synthesis of
8-Hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT), Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 22:12,
1723-1734
To link to this article: http://dx.doi.org/10.1080/00397919208020492
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