In vivo and in vitro effects of methacrylanilides and acetylcarboxanilide on alkaline phosphatase activity of Echinococcus multilocularis metacestodes

Article abstract of DOI:10.1016/0223-5234(92)90013-Q

In our search for effective chemotherapy of alveolar hydatid disease we are investigating key enzymes of Echinococcus multilocularis metacestodes.Isatin (2,3-indolinedione) is well known as an inhibitor of alkaline phosphatase activity, and has been previously investigated.Acetylcarboxanilide, an "open drug" of isatin and 2 methacrylanilides were evaluated for their ability to inhibit alkaline phosphatase activity of Echinococcus multilocularis metacestodes in vivo.These "open drugs" are more efficient than isatin, and para-chloromethacrylanilide exhibits a strongselectivity for the parasite enzyme and is also effective in vitro.The results obtained with para-chloromethacrylanilide are promising.Echinococcus multilocularis / alkaline phosphatase / synthetic inhibitors /anilides