Cyclooligomeric receptors for the sequence selective binding of peptides. A tetrahedral receptor from trimesic acid and 1,2-diamines

Article abstract of DOI:10.1016/S0040-4039(00)78435-8

The first members of a new family of tetrahedral receptors (2) have been prepared from trimesic acid and certain chiral 1,2-diamines. A survey of the binding properties of one of these with a 50,000-member peptide library finds high selectivity for N-acetylated terminal residues (particularly Ac-(D)Gln) and the dipeptide sequence (L)Gln-(L)Pro.