Synthesis of 1,2,3,9-tetrahydro-7-bromo-6-hydroxy-5-methoxypyrrolo-[2,1-b]- quinazol ine: A new analog of deoxyvasicine

Article abstract of DOI:10.1080/00397919508011391

A new deoxyvasicine analog (9) was synthesized by condensation of 2-amino-5-bromovanillin (6) with 4-aminobutyraldehyde (7) in phosphate buffer (pH 5.8) followed by hydrogenation of the resulting quinazolinium complex (8) at 65°C in presence of 5% palladium-on-barium sulfate.

Full text of DOI:10.1080/00397919508011391

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Synthetic Communications: An
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Synthesis of 1, 2, 3, 9-
Tetrahydro-7-bromo-6-
hydroxy-5-methoxypyrrolo-[2,
1-b]-quinazoline: A New Analog
of Deoxyvasicine
Babatunde Ojo a & Bejoy K. Chowdhury b
a Department of Medicinal and Biological Chemistry,
Center for Drug Design and Development , College
of Pharmacy, The University of Toledo , 2801 W.
Bancroft Street, Toledo, OH, 43606-3390, USA
b Department of Chemistry , School of Tropical
Medicine , Calcutta, 700 073, W. Bengal, INDIA
Published online: 23 Sep 2006.
To cite this article: Babatunde Ojo & Bejoy K. Chowdhury (1995) Synthesis of 1,
2, 3, 9-Tetrahydro-7-bromo-6-hydroxy-5-methoxypyrrolo-[2, 1-b]-quinazoline: A
New Analog of Deoxyvasicine, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 25:4, 569-572, DOI:
10.1080/00397919508011391
To link to this article: http://dx.doi.org/10.1080/00397919508011391
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